Genomic DNA samples from 74 OLP and 268 healthy controls were evaluated for IFN-纬 polymorphisms by polymerase chain reaction with sequence-specific primers (PCR-SSP) and direct sequencing method.
The T allele was significantly associated with an increased risk of OLP development as compared to the A allele (OR = 1.76, P = 0.004; Pc = 0.02). The effect of the T allele was similar to an autosomal recessive disorder; the presence of TT genotype (when compared to AA and AT) conferred an OR of 2.61, P = 0.008; Pc = 0.04.
We found an association between IFN-纬 +874A/T polymorphism and susceptibility to OLP. However, an association study utilising a larger sample size and patients from other races apart from the Asian population should be performed to further verify these findings.