Identification and phenotypic characterization of 纬未 T cells in rat lymph

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• 作者：Sudhanshu Shekhar ; ^{umshekha@cc.umanitoba.ca} ; Simon Milling¹ ; Chris Jenkins ; Gordon MacPherson
• 关键词：纬未 T cells ; Phenotype ; Lymph ; Rat
• 刊名：Research in Veterinary Science
• 出版年：2012
• 期刊代码：272_00345288
• 类别：med
• 出版时间：August, 2012
• 卷：93
• 期：1
• 页码：168-171
• 文件大小：321 K

摘要

纬未 T cells represent an unconventional subset of T lymphocytes that are abundant in epithelial tissues and serve as an early immune defense against microbes. We have, for the first time, identified 纬未 T cells in steady-state thoracic duct lymph (TDL) from rats. The lymph contains 纬未 T cells expressing CD8 but not CD4, CD25, MHC-II or CD103. The percentage of TDL 纬未 T cells in rats does not change when the mesenteric lymph nodes (MLN) are surgically removed. Our data suggest that a proportion of 纬未 T cells migrate from the intestine into rat TDL, under steady-state conditions.