Clinical pain and experimental pain sensitivity in progressive supranuclear palsy

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• 作者：Maria Stamelou^a ; ^b ; ^{m.stamelou@ion.ucl.ac.uk} ; Helena Dohmann^a ; Juliane Brebermann^a ; Evangelia Boura^a ; Wolfgang H. Oertel^a ; Gü ; nter Hö ; glinger^a ; Jens C. Mö ; ller^a ; ^c ; Veit Mylius^a ; ^d
• 关键词：Progressive supranuclear palsy ; Parkinson&rsquo ; s disease ; Nociception ; Pain sensitivity ; Nociceptive flexion reflex
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：5
• 页码：606-608
• 文件大小：118 K

摘要

<h4 class="h4">Objectiveh4>We aimed to assess spinal nociception and experimental pain sensitivity in progressive supranuclear palsy-Richardson鈥檚 syndrome (PSP-R) compared to patients with Parkinson鈥檚 disease (PD) and healthy controls (HC).<h4 class="h4">Methodsh4>

Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in non-demented, non-depressed, probable PSP-R patients (N聽=聽8), PD patients (N聽=聽19) and 17 HC.<h4 class="h4">Resultsh4>

PSP-R patients exhibited lower electrical pain thresholds and a tendency for lower NFR thresholds as compared to HC. No significant differences between PSP-R and PD patients were found with respect to experimentally-induced pain. However, significantly less PSP-R than PD patients reported disease-related pain.<h4 class="h4">Conclusionsh4>

Degeneration of the descending inhibitory control system within the brainstem in PSP-R might lead to increased experimental pain sensitivity while frontal cortical deterioration may alter self-estimation of pain.