Relation of 97T Polymorphism in KCNE5 to Risk of Atrial Fibrillation

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• 作者：Lasse S. Ravn ; Jacob Hofman-Bang ; Ulrik Dixen ; Severin Olesen Larsen ; Gorm Jensen ; Stig Haunsø ; Jesper Hastrup Svendsen and Michael Christiansen
• 刊名：The American Journal of Cardiology
• 出版年：2005
• 期刊代码：5_00029149
• 类别：med
• 出版时间：2005
• 卷：96
• 期：3
• 页码：405-407
• 文件大小：68 K

摘要

The 97T polymorphism of the KCNE5 gene, coding for an inhibitory b2;-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.