- 作者：Jung Kwang Nam ; M.D.a ; Chan Kwon Jung ; M.D. ; Ph.D.a ; Byung Joo Song ; M.D. ; Ph.D.a ; Dong Jun Lim ; M.D.b ; Byung Joo Chae ; M.D.a ; Nam Seop Lee ; M.D.a ; Woo Chan Park ; M.D. ; Ph.D.a ; Jeong Soo Kim ; M.D. ; Ph.D.a ; Sang Seol Jung ; M.D. ; Ph.D.a ; Ja Seong Bae ; M.D.a ; drbae@catholic.ac.kr
- 关键词：Thyroid cancer ; Papillary ; BRAFV600E mutation ; Lymph node metastasis
- 刊名：The American Journal of Surgery
- 出版年：2012
- 期刊代码：9_00029610
- 类别：med
- 出版时间：April, 2012
- 卷：203
- 期：4
- 页码：436-441
- 文件大小：222 K
Objective
Recent studies have shown that a BRAFV600E reflects poor prognosis, mainly in Western countries. However, some clinicians in Japan have suggested that the BRAFV600E mutation is not associated with a poor prognosis. Therefore, we investigated a relationship between BRAFV600E mutation and clinicopathologic factors.Methods
From September 2008 to December 2009, we performed routine analysis of the BRAFV600E mutation using thyroid cancer tissue from 424 patients who underwent thyroidectomy with cervical lymph node dissection.
Results
The BRAFV600E mutation was found in 335 of 424 cases (79%) and was higher in classic papillary thyroid carcinoma (PTC) (79.7%) than in the follicular variant of PTC (62.5%) (P = .019). On univariate analysis, the BRAFV600E mutation was associated with extrathyroidal extension (P = .009) and variants of PTC (P = .019), but a high-risk Metastasis, Patient Age, Completeness of resection, local Invasion and Tumor Size (MACIS) score (鈮?6) (P = .146) and lymph node metastasis (P = .628) were not significantly associated with the BRAFV600E mutation. Multivariate analysis showed that extrathyroidal extension is independently associated with the BRAFV600E mutation (relative ratio: 2.466; 95%confidence interval, 1.213-5.011; P < .013).
Conclusion
It is not clear that the BRAFV600E mutation is useful for prediction of poor prognosis of PTC.