Changes of 2-back task performance and physiological signals in ADHD children due to transient increase in oxygen level

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• 作者：Sung-Phil Kim^a ; ^{spkim@korea.ac.kr} ; Mi-Hyun Choi^b ; Ji-Hye Kim^b ; Hong-Won Yeon^b ; Hee-Jeong Yoon^b ; Hyung-Sik Kim^b ; Jang-Yeon Park^b ; Jeong-Han Yi^b ; Gye-Rae Tack^b ; Soon-Cheol Chung^b ; ^{scchung@kku.ac.kr}
• 关键词：Highly concentrated oxygen ; 2-Back task ; Response time ; Physiological signals ; ADHD children
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：9 March, 2012
• 卷：511
• 期：2
• 页码：70-73
• 文件大小：241 K

摘要

This study investigated the effect of 92%oxygen administration on 2-back task performance, blood oxygen saturation (SpO₂ [%]), and heart rate (HR [bpm]) of Attention Deficit Hyperactivity Disorder (ADHD) children. Subjects were thirteen boys (mean 12.9 卤 1.3 years) who were diagnosed as ADHD and are under treatment, having no disease or abnormality in a respiratory system or a periphery vascular flow system. The experiment consisted of two runs: one was a 2-back task under normal air (21%oxygen) condition and the other under hyperoxic air (92%oxygen) condition. The experiment sequence in each run consisted of three phases, which included the Adaptation phase (1 min) after oxygen administration, the Control phase (2 min) that maintained a stable condition before the task, and the Task phase (2 min) that performed 2-back task. SpO₂ and HR were measured during each phase. The analysis of cognitive performance with 92%oxygen administration when compared to 21%oxygen revealed that the response time decreased. When 92%oxygen in the air was supplied, the blood oxygen saturation increased while the heart rate decreased compared to those under the 21%oxygen condition. The response time also decreased for the subjects with a high SpO₂ during the Task phase. This showed that due to sufficient oxygen supply necessary for cognitive processing, SpO₂ increased and heart rate decreased. Therefore, an increase in cognitive ability such as a decrease in response time was observed in a transient period for ADHD children.