Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species
- 作者：Boram Lee ; Ki Hyun Kim ; Hye Jin Jung ; Ho Jeong Kwon ; kwonhj@yonsei.ac.kr
- 关键词：Ang 2 ; angiopoietin 2 ; CAM ; chorioallantoic membrane ; mROS ; mitochondrial reactive oxygen species ; RA ; retinoic acid ; VEGF ; vascular endothelial growth factor
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2012
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：27 April, 2012
- 卷：421
- 期：1
- 页码：76-80
- 文件大小：891 K
摘要
Mitochondrial reactive oxygen species (mROS) are involved in cancer initiation and progression and function as signaling molecules in many aspects of hypoxia and growth factor-mediated signaling. Here we report that matairesinol, a natural small molecule identified from the cell-based screening of 200 natural plants, suppresses mROS generation resulting in anti-angiogenic activity. A non-toxic concentration of matairesinol inhibited the proliferation of human umbilical vein endothelial cells. The compound also suppressed in vitro angiogenesis of tube formation and chemoinvasion, as well as in vivo angiogenesis of the chorioallantoic membrane at non-toxic doses. Furthermore, matairesinol decreased hypoxia-inducible factor-1伪 in hypoxic HeLa cells. These results demonstrate that matairesinol could function as a novel angiogenesis inhibitor by suppressing mROS signaling.