Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese

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• 作者：Shuai Chen^a ; ¹ ; Yu Zhang^a ; ¹ ; Wei Chen^a ; Ying Wang^a ; Jun Liu^a ; Tian-Yi Rong^a ; Jian-Fang Ma^a ; Gang Wang^a ; Jing Zhang^a ; Jing Pan^a ; Qin Xiao^a ; ^{xiaoqin67@medmail.com.cn} ; Sheng-Di Chen^a ; ^b ; ^{chen_sd@medmail.com.cn}
• 关键词：Parkinson's disease ; SNP ; SCARB2 ; Association study
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：10 May, 2012
• 卷：516
• 期：1
• 页码：21-23
• 文件大小：164 K

摘要

Recently, a nucleotide polymorphism rs6812193 near SCARB2 was found to be significantly associated with Parkinson's disease (PD) in populations of European ancestry. Herein, we conducted a case-control study with attempt to further evaluate the association between SNP rs6812193 and PD in a Chinese population from mainland China. rs6812193 was genotyped by PCR-RFLP technique in 449 PD patients and 452 controls in a Chinese population. In our study, we did not detect statistically significant differences between cases and controls in terms of both allele and genotype distribution of the rs6812193 polymorphism (P = 0.97 and P = 0.77, respectively), even after stratification by age at onset. Our data do not support the association of SNP rs6812193 with PD in Han Chinese of mainland China.