Elevation of serum TNF-伪 levels in mild and moderate Alzheimer patients with daytime sleepiness

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• 作者：Rui Chen ; You Yin¹ ; Zhongxin Zhao ; ^{zhongxinzhao@smmu.edu.cn} ; Liuqing Huang ; Shuqi Huang ; Jianhua Zhuang ; Huijuan Wu ; Hua Peng ; Peng Li
• 关键词：Sleepiness ; Alzheimer disease ; TNF-伪 ; IL-1尾
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：March, 2012
• 卷：244
• 期：1-2
• 页码：97-102
• 文件大小：219 K

摘要

Objectives

Sleep disturbance has been noted to accompany Alzheimer disease and is more pronounced as dementia severity increases. The aim of this study was to examine whether sleep disturbance in a cohort of patients with mild/moderate AD was associated with serum levels of IL-1尾 and TNF-伪.

Methods

Forty three drug-free AD patients and twenty two healthy controls were evaluated. All subjects underwent two consecutive full-night polysomnography. Their daytime sleepiness was assessed by Epworth Sleepiness Scale (ESS). Serum levels of IL-1尾 and TNF-伪 were measured by enzyme linked immunoassays.

Results

AD patients showed lower sleep efficiency, more awakenings and less slow wave sleep (SWS). IL-1尾 was detectable only in two AD patients. Serum TNF-伪 concentrations did not differ significantly between AD patients and controls. When AD patients were classified as AD patients with daytime sleepiness (n = 20, ESS > 10) or AD patients without daytime sleepiness (n = 23, ESS < 10) according to their ESS scores, serum levels of TNF-伪 was significantly higher in AD patients with daytime sleepiness than that in those without daytime sleepiness or controls (32.7 卤 17.9 vs 5.2 卤 2.4, p < 0.05; 40.9 卤 22.3 vs 5.7 卤 2.2, p < 0.05). Serum level of TNF-伪 was significantly correlated with ESS score.

Discussion

These data indicate that daytime sleepiness in mild and moderate AD patients is associated with elevation of serum TNF-伪 concentrations.