Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

详细信息	查看全文 | 推荐本文 |

• 作者：Maria Sundströ ; m^a ; ^{maria.sundstrom@mmk.su.se} ; Shu-Ching Chang^b ; ^{s.chang@mmm.com} ; Patricia E. Noker^c ; ^{noker@southernresearch.org} ; Gregory S. Gorman^c ; ^d ; ¹ ; ^{ggorman@samford.edu} ; Jill A. Hart^b ; ^{jahart@mmm.com} ; David J. Ehresman^b ; ^{djehresman@mmm.com} ; &Aring ; ke Bergman^a ; ^{ake.bergman@mmk.su.se} ; John L. Butenhoff^b ; ^{jlbutenhoff@mmm.com}
• 关键词：Perfluorohexanesulfonate ; PFHxS ; Pharmacokinetics ; Rats ; Monkeys ; Mice
• 刊名：Reproductive Toxicology
• 出版年：2012
• 期刊代码：233_08906238
• 类别：med
• 出版时间：July, 2012
• 卷：33
• 期：4
• 页码：441-451
• 文件大小：1049 K

摘要

Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The human geometric mean serum PFHxS elimination half-life has been estimated to be 2665 days. A series of studies was undertaken to establish pharmacokinetic parameters for PFHxS in rats, mice, and monkeys after single administration with pharmacokinetic parameters determined by WinNonlin^庐 software. Rats and mice appeared to be more effective at eliminating PFHxS than monkeys. With the exception of female rats, which had serum PFHxS elimination half-life of approximately 2 days, the serum elimination half-lives in the rodent species and monkeys approximated 1 month and 4 months, respectively, when followed over extended time periods (10-24 weeks). Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of PFHxS in humans.