Solvent-free Ugi four-component condensation: application to synthesis of philanthotoxins-12 analogues
- 作者：Nianjin Liu ; Song Cao ; Jingjing Wu ; Jinlong Yu ; Li Shen ; Xin Feng ; Xuhong Qian
- 关键词：
//www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-Acylamino amide ; Philanthotoxins analogues ; Solvent-free ; Ugi 4CR
- 刊名：Tetrahedron
- 出版年：2008
- 期刊代码：107_00404020
- 类别：ch
- 出版时间：28 April 2008
- 卷：64
- 期：18
- 页码：3966-3974
- 文件大小：283 K
摘要
Philanthotoxins-12 analogues was synthesized by a highly convergent approach, utilizing an efficient, simple, and convenient one-pot Ugi four-component solvent-free method as key step, followed by removal of the protecting groups in the presence of trifluoroacetic acid.