Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats

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• 作者：Ying Han ; Jiong Qin ; Xingzhi Chang ; Zhixian Yang ; Dingfang Bu and Junbao Du
• 关键词：Hydrogen sulfide ; Cystathionine b-synthase ; Gamma-aminobutyric acid ; Receptor ; Febrile seizure
• 刊名：Neuroscience Research
• 出版年：2005
• 期刊代码：53_01680102
• 类别：neu
• 出版时间：2005
• 卷：53
• 期：2
• 页码：216-219
• 文件大小：282 K

摘要

Hydrogen sulfide (H₂S) is recognized as a new neuromodulator in regulating various brain functions. Some of our recent studies showed that H₂S alleviates the hippocampal damage induced by recurrent febrile seizures (FS). In the present study, we used a rat model of recurrent FS and found that sodium sulfhydrate (NaHS, a donor of H₂S) down-regulated the expression of c-fos and increased the expression of gamma-aminobutyric acid B receptor subunits 1 (GABA_BR1) and 2 (GABA_BR2). Hydroxylamine (an inhibitor of cystathionine b-synthase) up-regulated the expression of c-fos and down-regulated the expression of GABA_BR2, but did not change the expression of GABA_BR1. These results suggest that H₂S plays a regulatory role through modulating GABA_BR function in the pathogenesis of recurrent FS.