Response of pathogenic and non-pathogenic yeasts to steroids

详细信息	查看全文 | 推荐本文 |

• 作者：Rajendra Prasad^a ; ^{rp47@mail.jnu.ac.in} ; ^{rp47jnu@gmail.com} ; Fr&eacute ; d&eacute ; ric Devaux^b ; Sanjiveeni Dhamgaye^a ; Dibyendu Banerjee^a ; ¹
• 关键词：VVC ; vulvovaginal candidiasis ; EBP ; estradiol binding protein ; CBP ; corticosteroid binding protein ; PBP ; progesterone binding protein ; ABC ; ATP-binding cassette ; MF ; major facilitator ; R6G ; rhodamine 6G ; 3D-QSAR ; three-dimensional quantitative structure a
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2012
• 期刊代码：172_09600760
• 类别：med
• 出版时间：March, 2012
• 卷：129
• 期：1-2
• 页码：61-69
• 文件大小：721 K

摘要

Steroids are known to induce pleiotropic drug resistance states in hemiascomycetes, with tremendous potential consequences on human fungal infections. The proteins capable of binding to steroids such as progesterone binding protein (PBP), estradiol binding proteins (ESP) are found in yeasts, however, the well known receptor mediated signaling present in higher eukaryotic cells is absent in yeasts and fungi. Steroids are perceived as stress by yeast cells which triggers general stress response leading to activation of heat shock proteins, cell cycle regulators, MDR transporters, etc. In this article, we review the response of yeast to human steroid hormones which affects its cell growth, morphology and virulence. We discuss that a fairly conserved response to steroids at the level of transcription and translation exists between pathogenic and non-pathogenic yeasts.

Article from a special issue on steroids and microorganisms.