The use of lidar as a sampling tool for large-area estimation may mitigate some or all of these problems. A number of factors drive, and are common to, the use of airborne profiling, airborne scanning, and spaceborne lidar systems as sampling tools for measuring and monitoring forest resources across areas that range in size from tens of thousands to millions of square kilometers. In this communication, we present the case for lidar sampling as a means to enable timely and robust large-area characterizations. We briefly outline the nature of different lidar systems and data, followed by the theoretical and statistical underpinnings for lidar sampling. Current applications are presented and the future potential of using lidar in an integrated sampling framework for large area ecosystem characterization and monitoring is presented. We also include recommendations regarding statistics, lidar sampling schemes, applications (including data integration and stratification), and subsequent information generation.