The antiatherosclerotic effect of Allium sativum

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• 作者：Koscielny ; J. ; Klü ; ß ; endorf ; D. ; Latza ; R. ; Schmitt ; R. ; Radtke ; H. ; Siegel ; G. ; Kiesewetter ; H.
• 关键词：Arteriosclerosis ; Carotid and femoral arteries ; Plaque volume ; Time- and age-dependent reduction ; Garlic powder ; Randomized ; double-blind ; placebo-controlled phase IV clinical trial ; B-mode ultrasound
• 刊名：Atherosclerosis
• 出版年：1999
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 1999
• 卷：144
• 期：1
• 页码：237-249
• 文件大小：403 K

摘要

In a randomized, double-blind, placebo-controlled clinical trial, the plaque volumes in both carotid and femoral arteries of 152 probationers were determined by B-mode ultrasound. Continuous intake of high-dose garlic powder dragées reduced significantly the increase in arteriosclerotic plaque volume by 5–18%or even effected a slight regression within the observational period of 48 months. Also the age-dependent representation of the plaque volume shows an increase between 50 and 80 years that is diminished under garlic treatment by 6–13%related to 4 years. It seems even more important that with garlic application the plaque volume in the whole collective remained practically constant within the age-span of 50–80 years. These results substantiated that not only a preventive but possibly also a curative role in arteriosclerosis therapy (plaque regression) may be ascribed to garlic remedies. ace="arial" size="-1" color="black"> Publisher: ace="arial" size="-1" color="black"> Elsevier Science ace="arial" size="-1" color="black"> Language of Publication: ace="arial" size="-1" color="black"> English ace="arial" size="-1" color="black"> Item Identifier: ace="arial" size="-1" color="black"> S0021-9150(99)00060-X ace="arial" size="-1" color="black"> Publication Type: ace="arial" size="-1" color="black"> Article ace="arial" size="-1" color="black"> ISSN: ace="arial" size="-1" color="black"> 0021-9150 ace="arial" size="-1" color="black"> Cited by: ace="arial" size="-1" color="black">

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ace="arial" size="-1" color="black"> Footnotes:

1. Correspondence to: Nicole G.C. Wevers, ETAF, European Training and Assessment Foundation, PO Box 182, 6700 AD, Wageningen, The Netherlands. Tel.: +31-317-450202; fax: +31-317-351173.