Chronic exposure to benzene results in a unique form of dysplasia
- 作者：Richard D. Irons ; Ling Lv ; Sherilyn A. Gross ; Xibiao Ye ; Liming Bao ; Xiao Qin Wang ; John Ryder ; Thomas W. Armstrong ; Yimei Zhou ; Lizhaung Miao et al.
- 关键词：Myelodysplastic syndrome ; Hematotoxicity ; Benzene ; Immunopathology
- 刊名：Leukemia Research
- 出版年：2005
- 期刊代码：186_01452126
- 类别：med
- 出版时间：2005
- 卷：29
- 期：12
- 页码：1371-1380
- 文件大小：497 K
摘要
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workers exposed to high concentrations of benzene. Distinguishing features of benzene-induced dysplasia include: marked dyserythropoiesis, eosinophilic dysplasia and abnormal cytoplasmic granulation of neutrophilic precursors. Hematophagocytosis, stromal degeneration and bone marrow hypoplasia are also seen. Severe bone marrow dysplasia is frequently accompanied by clonal T cell expansion and alterations in T lymphocyte subsets. No clonal cytogenetic abnormalities were observed. These results suggest that autoimmune-mediated bone marrow injury is an early or predisposing event in the pathogenesis of benzene-induced persistent hematopoietic disease.