Default mode network abnormalities in idiopathic generalized epilepsy

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• 作者：Megan L. McGill^a ; Orrin Devinsky^a ; Clare Kelly^b ; Michael Milham^b ; F. Xavier Castellanos^b ; Brian T. Quinn^a ; Jonathan DuBois^a ; Jonathan R. Young^a ; Chad Carlson^a ; Jacqueline French^a ; Ruben Kuzniecky^a ; Eric Halgren^c ; Thomas Thesen^a ; ^c ; ^{thomas.thesen@med.nyu.edu}
• 关键词：Idiopathic generalized epilepsy ; Default mode network ; Resting state functional connectivity
• 刊名：Epilepsy & Behavior
• 出版年：2012
• 期刊代码：76_15255050
• 类别：neu
• 出版时间：March, 2012
• 卷：23
• 期：3
• 页码：353-359
• 文件大小：714 K

摘要

Idiopathic generalized epilepsy (IGE) is associated with widespread cortical network abnormalities on electroencephalography. Resting state functional connectivity (RSFC), based on fMRI, can assess the brain's global functional organization and its disruption in clinical conditions. We compared RSFC associated with the 鈥榙efault mode network鈥?(DMN) between people with IGE and healthy controls. Strength of functional connectivity within the DMN associated with seeds in the posterior cingulate cortex (PCC) and medial prefrontal cortices (MPFC) was compared between people with IGE and healthy controls and was correlated with seizure duration, age of seizure onset and age at scan. Those with IGE showed markedly reduced functional network connectivity between anterior and posterior cortical seed regions. Seizure duration positively correlates with RSFC between parahippocampal gyri and the PCC but negatively correlates with connectivity between the PCC and frontal lobe. The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.