Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants

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• 作者：N. Bo啪ina^a ; ¹ ; N. Jovanovi膰^b ; ^c ; ¹ ; ^{nikolina.jovanovic@gmail.com} ; A. Podlesek^d ; M. Rojni膰 Kuzman^b ; ^c ; M. Kudumija Slijep膷evi膰^e ; A. Rogulji膰^c ; A. Dimitrovi膰^c ; T. Bo啪ina^f ; J. Lovri膰^f ; H. Ljubi膰^a ; V. Medved^b ; ^c
• 关键词：Suicide ideation ; Suicide attempt ; Schizophrenia ; Serotonin transporter ; Polymorphism ; 5-HTTLPR ; rs25531 ; Haplotype
• 刊名：Journal of Psychiatric Research
• 出版年：2012
• 期刊代码：169_00223956
• 类别：med
• 出版时间：June, 2012
• 卷：46
• 期：6
• 页码：767-773
• 文件大小：165 K

摘要

Aim

To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour.

Methods

The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS).

Results

Three subgroups were identified: suicide attempters (N聽=聽161), suicide ideators (N聽=聽174) and subjects who never reported suicide ideation or behaviour (comparative group, N聽=聽184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L_A allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL_G; 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L_AL_G, SL_A) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.

Conclusion

The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.