Multifractal analysis of the UV/VIS spectra of malignant ascites: Confirmation of the diagnostic validity of a clinically evaluated spectral analysis

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• 作者：Irini S. Reljin ; Branimir D. Reljin ; Milka L. Avramov-Ivi&#x107 ; Duš ; an V. Jovanovi&#x107 ; Goran I. Plavec ; Slobodan D. Petrovi&#x107 ; Gordana M. Bogdanovi&#x107
• 关键词：Ascites ; Neoplasm ; Medical diagnosis ; UV/VIS spectroscopy ; Fractals ; Multifractal analysis
• 刊名：Physica A
• 出版年：2008
• 期刊代码：138_03784371
• 类别：et
• 出版时间：1 June 2008
• 卷：387
• 期：14
• 页码：3563-3573
• 文件大小：819 K

摘要

Multifractal (MF) approach was applied for the analysis of ultraviolet/visible (UV/VIS) spectra as an independent confirmation of the diagnostic efficacy of UV/VIS spectral analysis of intraperitoneal fluids, ascites, taken from patients with a known clinical diagnosis. Recently, it was reported that from UV/VIS spectra differentiation of malignant from benign ascites is possible. Here, it was shown that by using MF analysis of UV/VIS spectra, the objective classification of UV/VIS spectra is possible. The applicability of UV/VIS analysis and MF classification of spectra were evaluated on N=68 cases, of which M=64 and B=4 were clinically confirmed as malignant and benign, respectively. The overall diagnostic efficacy was 89.71%when using on-line analysis of UV/VIS spectra (61 out of 68 samples were positively recognized: 58 malignant and 3 benign), and even 95.59%by using off-line MF classsification (65 out of 68 samples were classified correctly: 63 malignant and 2 benign). It can be inferred that UV/VIS spectral analysis of ascites, combined with MF analysis, could be suggested as a successful and safe screening method in the evaluation of intraperitoneal fluids.