Apathy in first episode psychosis patients: A ten year longitudinal follow-up study

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• 作者：Julie Evensen^a ; ^b ; ^{j.h.evensen@medisin.uio.no} ; Jan Ivar Rø ; ssberg^a ; Helene Barder^a ; Ulrik Haahr^k ; Wenche ten Velden Hegelstad^c ; Inge Joa^c ; Jan Olav Johannessen^c ; ⁱ ; T.K. Larsen^c ; ^d ; Ingrid Melle^a ; Stein Opjordsmoen^a ; Bjø ; rn Rishovd Rund^g ; ^h ; Erik Simonsen^j ; Kjetil Sundet^a ; ^g ; Per Vaglum^f ; Svein Friis^a ; Thomas McGlashan^e
• 关键词：Apathy ; Negative symptoms ; Outcome ; First episode psychosis
• 刊名：Schizophrenia Research
• 出版年：2012
• 期刊代码：240_09209964
• 类别：med
• 出版时间：April, 2012
• 卷：136
• 期：1-3
• 页码：19-24
• 文件大小：271 K

摘要

Background

Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.

Objective

The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.

Methods

Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy).

Patients were classified as having apathy (AES-S-Apathy 鈮?#xA0;27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.

Results

Nearly 30%of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.

Conclusions

Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.