Synthesis of nucleoside derivatives via heterocyclocondensation reactions
- 作者：Vincent Kikelj ; Paul Setzer ; Karine Julienne ; Jean-Claude Meslin ; David Deniaud
- 关键词：Nucleosides ; Cyclocondensations ; Diazadienes ; Thiazadienes ; Glycosyl heterocycles ; Glycosylamino heterocycles
- 刊名：Tetrahedron Letters
- 出版年：2008
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：12 May 2008
- 卷：49
- 期：20
- 页码：3273-3275
- 文件大小：110 K
摘要
A new synthesis of nucleoside analogues has been developed. The cyclocondensation of a glycosylated diazadiene or thiazadiene, with acyl chlorides or 
-halogenoketones, respectively, resulted in good yields and excellent regioselectivities. We report an efficient method for the production of glucosyl pyrimidinones and glucosylamino thiazoles.
-halogenoketones, respectively, resulted in good yields and excellent regioselectivities. We report an efficient method for the production of glucosyl pyrimidinones and glucosylamino thiazoles.