Viral disruption of the blood-brain barrier
- 作者：Katherine R. Spindler krspin@umich.edu ; Tien-Huei Hsu
- 关键词：blood&ndash ; brain barrier ; viral encephalitis ; tight junctions ; matrix metalloproteinases.
- 刊名：Trends in Microbiology
- 出版年：2012
- 期刊代码：258_0966842x
- 类别：med
- 出版时间：June, 2012
- 卷：20
- 期：6
- 页码：282-290
- 文件大小：329 K
摘要
The blood-brain barrier (BBB) provides significant protection against microbial invasion of the brain. However, the BBB is not impenetrable, and mechanisms by which viruses breach it are becoming clearer. In vivo and in vitro model systems are enabling identification of host and viral factors contributing to breakdown of the unique BBB tight junctions. Key mechanisms of tight junction damage from inside and outside cells are disruption of the actin cytoskeleton and matrix metalloproteinase activity, respectively. Viral proteins acting in BBB disruption are described for HIV-1, currently the most studied encephalitic virus; other viruses are also discussed.