Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid

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• 作者：Krysko ; Andrei A. ; Chugunov ; Boris M. ; Malovichko ; Olga L. ; Andronati ; Sergei A. ; Kabanova ; Tatyana A. ; et. al.
• 关键词：Fibrinogen receptor antagonists ; GP IIb/IIIa ; RGD mimetics ; Isoindoline ; Platelet aggregation
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：November 15, 2004
• 卷：14
• 期：22
• 页码：5533-5535
• 文件大小：249 K

摘要

The novel RGDF mimetics 9a and 9b were synthesized with the use of 4-(isoindoline-5-yl)amino-4-oxobutyric acid as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to 脦脦_IIb脦脦₃ on washed human platelets.