α-Synuclein expression in the brain and blood during abstinence from chronic alcohol drinking in mice
- 作者：Barbara Ziolkowska ; Agnieszka Gieryk ; Agnieszka Wawrzczak-Bargiela ; Tomasz Krowka ; Dorota Kaminska ; Agnieszka Korkosz ; Przemyslaw Bienkowski ; Ryszard Przewlocki
- 关键词：
//www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-Synuclein ; Alcohol drinking ; Two-bottle choice ; Abstinence ; Amygdala ; Craving
- 刊名：Neuropharmacology
- 出版年：2008
- 期刊代码：33_00283908
- 类别：pha
- 出版时间：June 2008
- 卷：54
- 期：8
- 页码：1239-1246
- 文件大小：574 K
摘要
-Synuclein is a presynaptic protein proposed to serve as a negative regulator of dopaminergic neurotransmission. Recent research has implicated -synuclein in chronic neuroadaptations produced by psychostimulant and opiate use, as well as in genetically determined susceptibility to alcoholism in humans. The aim of our study was to characterize the changes in -synuclein expression after short-term abstinence from chronic alcohol drinking in mice.