Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity
- 作者：Oda ; Kenji ; Okubo ; Yoshiro ; Ishida ; Ryuji ; Murata ; Yuji ; Ohta ; Katsuya ; Matsuda ; Tetsuya ; Matsushima ; Eisuke ; et. al.
- 关键词：Depression ; regional cerebral blood flow ; single photon emission computed tomography ; magnetic resonance imaging ; white matter hyperintensity ; vascular depression
- 刊名：Biological Psychiatry
- 出版年：2003
- 期刊代码：34_00063223
- 类别：med
- 出版时间：January 15, 2003
- 卷：53
- 期：2
- 页码：150-156
- 文件大小：195 K
摘要
Functional neuroimaging studies have consistently demonstrated decreased regional cerebral blood flow (rCBF) or metabolism in the frontal lobe, temporal lobe, or anterior cingulate gyrus of depressed patients. On the other hand, white matter hyperintensity as defined by magnetic resonance imaging (MRI) has been the most consistently replicated finding in structural neuroimaging studies on depression; however, these functional and structural neuroimaging findings of depression have not been well integrated. We aimed to clarify the possible associations of MRI-defined subcortical hyperintensities with rCBF changes in depressed patients.