Characteristics of earlier atherosclerotic involvement in adolescent patients with Kawasaki disease and coronary artery lesions: Significance of gray scale median on B-mode ultrasound

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• 作者：Nobutaka Noto ; ^{info@noto-clinic.com} ; Tomoo Okada ; Yuriko Abe ; Michio Miyashita ; Hiroshi Kanamaru ; Kensuke Karasawa ; Mamoru Ayusawa ; Naokata Sumitomo ; Hideo Mugishima
• 关键词：Kawasaki disease ; Atherosclerosis ; Gray scale median ; Intima&ndash ; media complex
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 2012
• 卷：222
• 期：1
• 页码：106-109
• 文件大小：302 K

摘要

Objective

To test the hypothesis that textural changes in the carotid intima-media complex (IMC) detected by B-mode ultrasound are associated with the difference of remodeling process in earlier atherosclerotic involvement in patients with Kawasaki disease (KD) and coronary artery lesions (CALs).

Methods

Eighteen patients with KD and CALs (mean age 17.2 years), 17 patients with heterozygous familial hypercholesterolemia (FH) (mean age 16.9 years) and 15 age-matched healthy controls (Cont) were assessed and compared for carotid intima-media thickness (CIMT), elastic property (E_p), and first- and second-order statistics.

Results

KD showed significantly higher gray scale median (GSM) than FH and Cont. KD and FH showed significantly higher CIMT, entropy and lower angular second moment than Cont, but no significant difference was found between KD and FH.

Conclusion

Higher GSM in KD may indicate alteration of tissue components and heterogeneity of IMC, suggesting the development of arteriosclerotic vascular remodeling after vasculitis. This is distinct from that of atherosclerosis with lower GSM often observed in FH.