Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study

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• 作者：Kenji Wada-Isoe ; Michio Kitayama ; Kazuhiro Nakaso ; Kenji Nakashima
• 关键词：Amyloid β ; Tau ; H/M ratio ; Washout rate ; Sympathetic nerve ; Alzheimer's disease
• 刊名：Journal of the Neurological Sciences
• 出版年：2007
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 September 2007
• 卷：260
• 期：1-2
• 页码：33-37
• 文件大小：242 K

摘要

This study examined the diagnostic value of cerebrospinal fluid (CSF) markers and iodine-123 metaiodobenzylguanidine (¹²³I-MIBG) cardiac scintigraphy in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD).

Methods

CSF levels of amyloid β1-42 (Aβ42) and 181-Thr phosphorylated tau (p-tau) were measured using enzyme linked immunosorbent assay (ELISA) kits. ¹²³I-MIBG cardiac scintigraphy was performed in patients with AD and DLB, and control (CTL) subjects.

Results

Increased CSF levels of p-tau in AD were found compared to DLB patients and CTL subjects (P < 0.01), but there was no significant difference in CSF levels of Aβ42 between AD and DLB patients. The early and delayed heart to mediastinum (H/M) ratios of ¹²³I-MIBG cardiac scintigraphy were significantly decreased in patients with DLB compared to AD patients and CTL subjects (P < 0.01). The receiver operating characteristic (ROC) analysis revealed that the diagnostic value of ¹²³I-MIBG cardiac scintigraphy was superior to that of CSF markers.

Conclusions

¹²³I-MIBG cardiac scintigraphy may be useful for discriminating between DLB and AD.