Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation

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• 作者：Cheng ; Jiayi ; Kondo ; Kazunao ; Suzuki ; Yasuhiro ; Ikeda ; Yasuhiko ; Meng ; Xiansheng ; Umemura ; Kazuo
• 关键词：Sea buckthorn ; Thrombosis ; Platelet aggregation ; Flavones
• 刊名：Life Sciences
• 出版年：2003
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：April 4, 2003
• 卷：72
• 期：20
• 页码：2263-2271
• 文件大小：137 K

摘要

Total flavones of Hippophae Rhamnoides L (TFH) are extracted from Sea buckthorn, a Chinese herbal medicine. Sea buckthorn has antioxidant, anti-ulcerogenic and hepato-protective actions, and its berry oil is reported to suppress platelet aggregation. Though it is frequently used for patients with thrombosis, the likely mechanism(s) and effects of TFH on thrombogenesis remain unclear. Thus, we have investigated the effect in-vivo of TFH on thrombogenesis and in vitro on platelet aggregation, comparing them to those of aspirin.