Temporal National Trends of Minimally Invasive and Retropubic Radical Prostatectomy Outcomes from 2003 to 2007: Results from the 100%Medicare Sample

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• 作者：Keith J. Kowalczyk^a ; Jesse M. Levy^b ; Craig F. Caplan^b ; Stuart R. Lipsitz^c ; Hua-yin Yu^d ; Xiangmei Gu^c ; Jim C. Hu^c ; ^d ; ^{jhu2@partners.org}
• 关键词：Prostate cancer ; Radical prostatectomy ; Complications ; Medicare
• 刊名：European Urology
• 出版年：2012
• 期刊代码：289_03022838
• 类别：med
• 出版时间：April, 2012
• 卷：61
• 期：4
• 页码：803-809
• 文件大小：458 K

摘要

Background

Although the use of minimally invasive radical prostatectomy (MIRP) has increased, there are few comprehensive population-based studies assessing temporal trends and outcomes relative to retropubic radical prostatectomy (RRP).

Objective

Assess temporal trends in the utilization and outcomes of MIRP and RRP among US Medicare beneficiaries from 2003 to 2007.

Design, setting, and participants

A population-based retrospective study of 19 594 MIRP and 58 638 RRP procedures was performed from 2003 to 2007 from the 100%Medicare sample, composed of almost all US men 鈮?5 yr of age.

Intervention

MIRP and RRP.

Measurements

We measured 30-d outcomes (cardiac, respiratory, vascular, genitourinary, miscellaneous medical, miscellaneous surgical, wound complications, blood transfusions, and death), cystography utilization within 6 wk of surgery, and late complications (anastomotic stricture, ureteral complications, rectourethral fistulae, lymphocele, and corrective incontinence surgery).

Results and limitations

From 2003 to 2007, MIRP increased from 4.9%to 44.5%of radical prostatectomies while RRP decreased from 89.4%to 52.9%. MIRP versus RRP subjects were younger (p < 0.001) and had fewer comorbidities (p < 0.001). Decreased MIRP genitourinary complications (6.2-4.1%; p = 0.002), miscellaneous surgical complications (4.7-3.7%; p = 0.030), transfusions (3.5-2.2%; p = 0.005), and postoperative cystography utilization (40.3-34.1%; p < 0.001) were observed over time. Conversely, overall RRP perioperative complications increased (27.4-32.0%; p < 0.001), including an increase in perioperative mortality (0.5-0.8%, p = 0.009). Late RRP complications increased, with the exception of fewer anastomotic strictures (10.2-8.8%; p = 0.002). In adjusted analyses, RRP versus MIRP was associated with increased 30-d mortality (odds ratio [OR]: 2.67; 95%confidence interval [CI], 1.55-4.59; p < 0.001) and more perioperative (OR: 1.60; 95%CI, 1.45-1.76; p < 0.001) and late complications (OR: 2.52; 95%CI, 2.20-2.89; p < 0.001). Limitations include the inability to distinguish MIRP with versus without robotic assistance and also the lack of pathologic information.

Conclusions

From 2003 to 2007, there were fewer MIRP transfusions, genitourinary complications, and miscellaneous surgical complications, whereas most RRP perioperative and late complications increased. RRP versus MIRP was associated with more postoperative mortality and complications.