• 作者：Pascal Clayette ; Audrey Agopian ; Nathalie Dereuddre-Bosquet ; Chritine Goffinet ; Rahima Yousfi ; Jé ; rome Depollier ; Karen Storck ; Eric Gros ; Oliver Keppler ; Gilles Divita
• 关键词：Rice flour ; Soybean ; Pea ; Proteins ; Transglutaminase ; Functional properties ; Rheology ; Microstructure
• 刊名：Antiviral Research
• 出版年：2008
• 期刊代码：7_01663542
• 类别：imm
• 出版时间：May 2008
• 卷：78
• 期：2
• 页码：A27
• 文件大小：72 K

The application of the two-drug combination sequences maintained stable CD4 levels in two subjects whose viral load (the evaluation of which had became available) was, at the end of this period, of 4,486 and 39,238 RNA copies. The third subject who had received, an intensive UV irradiation for a psoriasis, presented an irreversible decrease in his CD4 count and a high viral load (1,352,495 RNA copies/mL) at the end of the two-drug period.

Fifteen to 25 months after the shift to the three-drug combinations, the viral load decreased, from 39,328 to 13,291 in one of the non-UV irradiated subjects, and from 1,352,495 to 314,387 in the irradiated one. No subject had an increase in CD4 number.

In the three patients having initially received the three-drug combinations, a very strong decrease of viral load was registered after periods of observation varying from 77 to 40 months, while the CD4 counts increased moderately in two subjects, and noticeably in the third (from 126 to 266).

Out of the four subjects initially treated with four-drug combinations, the two with less than 10 CD4/mm³ had a moderate decrease in viral load in about three months, and the CD4 increased from 9 to 34/mm³ in one. But the two subjects, because of opportunistic infections and psychological reasons, abandoned their treatments.

In the two subjects who had more than 100 CD4/mm² at initiation of the four-drug combination treatment, the viral load decreased to undetectable levels after four months: but their CD4 counts, after some oscillations, had very moderately increased at the end of the observation period (respectively, from 200 to 222, and from 129 to 134).

In practice, these results suggest the interest of conducting phase II or III studies of AIDS treatment protocols, starting with the four-drug combination model, and attempting to maintain the effect with the three-drug combination one.

As for theoretical considerations, one must underline the contrast between the remarkable reduction of the viral load and the usually moderate increase of the CD4 counts.

The study but not the trial has been interrupted, due to the unavailability of three antiproteases, saquinavir, ritonavir and indinavir, which are now introduced in the same type of combinations, one by one, in replacement of one of the studied agents as shown in figure 1. The effect of increasing the total number of virostatics from five to eight will be published in the second part of this article series.