Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine

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• 作者：Oliver Brandt ; MD^a ; ^{Lwo.brandt@gmx.de} ; Michael Mildner ; PhD^a ; Alexander E. Egger ; MD ; PhD^b ; Michael Groessl ; PhD^b ; Uwe Rix ; PhD^c ; Martin Posch ; PhD^d ; Bernhard K. Keppler ; MD ; PhD^b ; Christian Strupp ; PhD^e ; Beat Mueller ; PhD^e ; Georg Stingl ; MD^a
• 关键词：Silver ions ; Antimicrobial potency ; Percutaneous absorption ; Internal organ deposition
• 刊名：Nanomedicine ; Nanotechnology ; Biology and Medicine
• 出版年：2012
• 期刊代码：11_15499634
• 类别：et
• 出版时间：May, 2012
• 卷：8
• 期：4
• 页码：478-488
• 文件大小：1055 K

摘要

Silver has been used successfully for decades as an antibacterial agent and has become a standard treatment for burns and bacterial skin infections. Silver-containing creams, particularly silver sulfadiazine (SSD), possess effective activities against bacteria and fungi. However, there is serious concern that silver ions applied to denuded skin might be absorbed in significant amounts, thus introducing the risk of silver deposition, potentially leading to internal organ injury. In view of these facts we compared the percutaneous absorption and the antimicrobial potency of SSD with a new composition, nanoscalic silver (NSAg). In a murine model topical application of NSAg resulted in significantly lower percutaneous absorption and internal organ deposition compared to SSD. Strikingly, antimicrobial activity of NSAg used as a 0.1%formulation was comparable not only with 0.1%SSD against different bacterial strains including methicillin-resistant Staphylococcus aureus, but also against different yeast and dermatophyte species.

From the Clinical Editor

Nanoscale silver (NSAg) was demonstrated to have significantly lower percutaneous absorption and less accumulation in multiple organs when applied to denuded skin. Its antimicrobial activity against MRSA was not only comparable to silver sulfadiazine, but the formulation was also effective against different yeast and dermatophyte species.