Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal infection
- 作者：Adam Linder ; Susan Hollingshead ; Robert Janulczyk ; Bertil Christensson ; Per Å ; kesson
- 关键词：Streptococcus pneumoniae ; PspA ; PspC ; Antibody response
- 刊名：Vaccine
- 出版年：2007
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：4 January 2007
- 卷：25
- 期：2
- 页码：341-345
- 文件大小：259 K
摘要
IgG antibodies against pneumococcal surface protein A, family 1 (PspA1) and family 2 (PspA2), protein C (PspC), and protein Hic were investigated in 41 patients with invasive pneumococcal disease. Pre-existing antibody levels against the four pneumococcal proteins were not significantly different from those found in 40 patients with non-pneumococcal bacteremia or 80 healthy controls. However, during convalescense a strong immune response developed especially against PspA, and there was a high degree of cross-reactivity between PspA- and PspC-antibodies. Our findings on immunogenicity and cross-reactivity suggest that in a future pneumococcal protein based vaccine, only a limited number of proteins could be sufficient.