Three-Dimensional ¹³C-Spectroscopic Imaging in the Isolated Infarcted Rat Heart

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• 作者：Weidensteiner ; Claudia ; Lanz ; Titus ; Horn ; Michael ; Neubauer ; Stefan ; Haase ; Axel ; von Kienlin ; Markus
• 刊名：Journal of Magnetic Resonance
• 出版年：2000
• 期刊代码：126_10907807
• 类别：ch
• 出版时间：March, 2000
• 卷：143
• 期：1
• 页码：17-23
• 文件大小：269 K

摘要

Acquisition weighted ¹³C-spectroscopic imaging with three spatial dimensions is demonstrated in the isolated, perfused rat heart. Experiments were performed at 11.75 T with a homebuilt double resonant ¹³C–¹H probehead. Three-dimensional chemical shift imaging was used to obtain ¹H-decoupled ¹³C-spectra in 96-μl voxels in about 58 min. Acquisition weighting significantly reduced signal contamination and improved image quality, with no penalty in sensitivity. As a first application, infarcted hearts were studied during perfusion with [2-¹³C]-sodium acetate. The extent of the incorporation of the ¹³C-label into glutamate allows us to distinguish intact and infarcted myocardium. Chemical shift images show a homogeneous glutamate distribution in intact tissue, but a neglible amount in the infarction scar.