We
repo
rt on a jumping t
ranslocation with five diffe
rent cell lines detected in fou
r tissues in a 2-yea
r-old patient. This
ra
re type of ch
romosomal abno
rmality (not mo
re than 30 cases published so fa
r) p
roved to be a se
ries of non-
recip
rocal t
ranslocations of the 15q24-qte
r dono
r ch
romosome segment to the telome
ric
region of ch
romosomes 5q, 10q, 16q and 19p,
respectively. The p
rocess, in addition to a few cells without t
ranslocation,
resulted in pa
rtial t
risomy of 15q24-qte
r which was associated with somatic ove
rdevelopment in the patient, with hemihype
rt
rophy and mino
r anomalies.
The phenotype of our patient was different from that of the other two patients found in the literature having the same donor chromosome segment involved in a similar rearrangement. Possibly, the difference in the phenotype lies in the various ratios of somatic mosaicism with five cell lines, in particular the presence of normal one which is extremely rare in patients with jumping translocation. Here we discuss the various ways on how the rearrangement could arise.