Parental history of Type 2 diabetes in patients with nonaffective psychosis

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• 作者：Emilio Fern ; ez-Egea ; Brian Miller ; Miguel Bernardo ; Thomas Donner ; Brian Kirkpatrick
• 关键词：Nonaffective psychosis ; Schizophrenia ; Type 2 diabetes ; Family history ; Epidemiology
• 刊名：Schizophrenia Research
• 出版年：2008
• 期刊代码：240_09209964
• 类别：med
• 出版时间：January 2008
• 卷：98
• 期：1-3
• 页码：302-306
• 文件大小：133 K

摘要

We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands.

Methods

N = 34 patients with newly-diagnosed nonaffective psychosis and N = 52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes.

Results

In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p < 0.04).

Discussion

We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.