Cortical structural abnormalities in deficit versus nondeficit schizophrenia

详细信息	查看全文 | 推荐本文 |

• 作者：Bernard A. Fischer^a ; ^b ; William R. Keller^b ; Celso Arango^c ; Godfrey D. Pearlson^d ; Robert P. McMahon^b ; Walter A. Meyer^b ; Alan Francis^e ; Brian Kirkpatrick^f ; William T. Carpenter^a ; ^b ; Robert W. Buchanan^b ; ^{rwbuchanan@mprc.umaryland.edu}
• 关键词：Schizophrenia ; Deficit syndrome ; Frontal lobe ; Temporal lobe ; Structural MRI
• 刊名：Schizophrenia Research
• 出版年：2012
• 期刊代码：240_09209964
• 类别：med
• 出版时间：April, 2012
• 卷：136
• 期：1-3
• 页码：51-54
• 文件大小：153 K

摘要

Objective

To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia.

Method

A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls.

Results

The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures.

Conclusion

People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.