Induced transcriptional expression of calcium-binding protein S100A1 and S100A10 genes in human renal cell carcinoma

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• 作者：Teratani ; Takumi ; Watanabe ; Takumi ; Kuwahara ; Fuminari ; Kumagai ; Hiromichi ; Kobayashi ; Shuzou ; et. al.
• 关键词：S100A1 ; S100A10 ; Renal cell carcinoma
• 刊名：Cancer Letters
• 出版年：2002
• 期刊代码：44_03043835
• 类别：med
• 出版时间：January 10, 2002
• 卷：175
• 期：1
• 页码：71-77
• 文件大小：322 K

摘要

Expression of 16 S100 family calcium-binding protein genes was evaluated by PCR in ten human tissue cDNA libraries. Six to 12 S100 genes were expressed in a tissue-specific manner. Then, the expression in the surgically resected renal cell carcinoma (RCC) and a cultured RCC cell line was studied by RT-PCR. Although eight to nine S100 genes were transcribed in the normal kidney library and non-cancerous part of resected kidney tumors, S100A1 and S100A10 genes were not expressed. However, these genes were newly expressed in the RCC lesions (n=7) and the RCC cell line, indicating that expression of S100A1 and S100A10 genes is accompanied by RCC.