Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes
- 作者：Ako Kikuchi ; Naoya Nakamura ; Tetsuo Kuze ; Yoshikazu Sasaki ; Masafumi Abe ; Hitoshi Ohno ; Takashi Akasaka ; Shigeo Nakamura ; Koichi Ohshima ; Kiyoshi Ando
- 关键词：c-myc ; Diffuse large B-cell lymphoma ; Immunoglobulin heavy chain gene ; Immunohistochemistry
- 刊名：Leukemia Research
- 出版年：2008
- 期刊代码：186_01452126
- 类别：med
- 出版时间：August 2008
- 卷：32
- 期：8
- 页码：1176-1182
- 文件大小：978 K
摘要
The characteristics of de novo diffuse large B-cell lymphoma (DLBCL) with translocation of c-myc and immunoglobulin (Ig) genes (c-myc/Ig DLBCL), were investigated in 13 cases of c-myc/Ig DLBCL. Immunohistochemistry revealed five cases were positive for CD10 and BCL6 expression (CD10+/BCL6+), five cases of CD10−/BCL6+/MUM1−, one case of CD10−/BCL6+/MUM1+ and two cases of CD10−/BCL6−/MUM1+ expression, indicating 10 cases of germinal center B-cell DLBCL and three cases of non-germinal center B-cell DLBCL. Ongoing mutation of the Ig heavy chain gene variable region (IgH-V) was found in two cases with CD10 and BCL6 expression and one case showing CD10−/BCL6+/MUM1− expression. These three cases of ongoing mutation of the IgH-V gene did not express BCL2, unlike those without ongoing mutation. These results suggest a heterogeneous immunophenotype and genotype for c-myc/Ig DLBCL, with CD10−/BCL6+/MUM1− cases the most frequent.