2-Aminopyridine derivative as fluorescence 鈥極n-Off鈥?molecular switch for selective detection of Fe³⁺/Hg²⁺

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• 作者：Rik Rani Koner ; Sougata Sinha ; Sunil Kumar ; Chayan K. Nandi ; ^{chayan@iitmandi.ac.in} ; Subrata Ghosh ; ^{subrata@iitmandi.ac.in}
• 关键词：Fluorescence chemosensor ; Molecular switch ; Quenching ; Aminopyridine
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2 May, 2012
• 卷：53
• 期：18
• 页码：2302-2307
• 文件大小：874 K

摘要

2-Amino-6-methyl-4-phenyl-nicotinonitrile class="boldFont">1, a 2-aminopyridine-based fluorescent compound, was found to be a fluorescent chemosensor for the detection of Fe³⁺ and Hg²⁺ ions over a number of other metal ions. Compound class="boldFont">1 was synthesized in one step using a multicomponent reaction, and characterized using common spectroscopic tools. During Fe³⁺/Hg²⁺ sensing the compound class="boldFont">1 followed a 鈥榮witch-off鈥?mechanism. Further, compound class="boldFont">1 could sense Fe³⁺ over Hg²⁺ by its distinct absorption and fluorescence quenching behaviors. 1:1 complex formation of class="boldFont">1 with Fe³⁺ and Hg²⁺ was clearly understood from Job鈥檚 plot. The present work brings additional evidence on the importance of multicomponent reactions which could lead to the development of fluorescence chemosensor in one step for the selective detection of biologically important metal ions.