New genetic group of measles virus isolated in the People's Republic of China

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• 作者：Xu ; Wen-bo ; Tamin ; Azaibi ; Rota ; Jennifer S. ; Zhang ; LiBi ; Bellini ; William J. ; Rota ; Paul A.
• 关键词：Measles virus ; People's Republic of China
• 刊名：Virus Research
• 出版年：1998
• 期刊代码：92_01681702
• 类别：imm
• 出版时间：April, 1998
• 卷：54
• 期：2
• 页码：147-156
• 文件大小：126 K

摘要

Genetic and antigenic characterization of 14 wild-type measles viruses isolated from four provinces in the People's Republic of China during 1993 and 1994 was conducted. Sequence analyses of the hemagglutinin (H) and nucleoprotein (N) genes indicated that 13 of the 14 Chinese viruses comprised a previously undescribed genetic group. Viruses from this unique group were the most genetically diverse measles viruses described, so far. The Chinese viruses differed from other wild-type viruses by as much as 6.9%in the H gene and 7.0%in the N gene at the nucleotide level. One of the 14 viruses was a member of the same genetic group that contains the Edmonston strain. Antigenic analysis using monoclonal antibodies to the H protein did not detect significant differences in binding patterns between the Chinese viruses and other wild-type measles viruses. In addition, representative viruses from the unique Chinese group were neutralized by both human post-vaccination antiserum and mouse antiserum against the H protein of the Edmonston vaccine virus. Viruses closely related to these Chinese viruses were also associated with importations of measles into the United States during 1997 from Vietnam and Hong Kong suggesting that viruses from this new genetic group continue to circulate in China and possibly other parts of Asia. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0168-1702(98)00020-3 Publication Type: Article ISSN: 0168-1702 Cited by:

1. Na, Byoung-Kuk; Lee, Jin-Soo; Shin, Gu-Choul; Mi Shin, Ju; Lee, Joo-Yeon; Chung, Jae-Keun; Ha, Dong-Ryong; Lee, Jong-Koo; Ma, Sang-Hyuk; Cho, Hae-Wol; Kang, Chun; Kim, Woo-Joo,"Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic"Virus Research2001pp. 143-149
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2. Liffick, Stephanie L.; Thi Thoung, Nguyen; Xu, Wenbo; Li, Yeqiang; Phoung Lien, Huynh; Bellini, William J.; Rota, Paul A.,"Genetic characterization of contemporary wild-type measles viruses from Vietnam and the People's Republic of China: identification of two genotypes within clade H²"Virus Research2001pp. 81-87
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3. Truong, Anh T.; Mulders, Mick N.; Gautam, Dinesh C.; Ammerlaan, Wim; de Swart, Rik L.; King, Chwan-Chuen; Osterhaus, Albert D.M.E.; Muller, Claude P.,"Genetic analysis of Asian measles virus strains - new endemic genotype in Nepal"Virus Research2001pp. 71-78
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4. Mulders, Mick N.; Truong, Anh T.; Muller, Claude P.,"Monitoring of measles elimination using molecular epidemiology"Vaccine2001pp. 2245-2249
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5. Kumada, Atsushi; Komase, Katsuhiro; Nakayama, Tetsuo,"Recombinant measles AIK-C strain expressing current wild-type hemagglutinin protein"Vaccine2004pp. 309-316
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Footnotes:

1. Sequence data have been deposited in GenBank under accession numbers HAF045191–HAF045218.

2. The sequences described in this paper have been deposited in GenBank under accession numbers AY026867-AY026894.