- 作者：Yen-Hung Lin ; Kuan-Yin Pao ; Vin-Cent Wu ; Yu-Li Lin ; Yu-Fen Chien ; Chi-Sheng Hung ; Yu-Jen Chen ; Chung-Pin Liu ; I-Jung Tsai ; Churn-Shiouh Gau ; et al.
- 关键词：eCrCl ; Folic acid ; Homocysteine ; Serum creatinine ; Vitamin B12
- 刊名：Clinical Biochemistry
- 出版年：2007
- 期刊代码：55_00099120
- 类别：med
- 出版时间：February 2007
- 卷：40
- 期：3-4
- 页码：230-234
- 文件大小：190 K
To examine the relation of estimated creatinine clearance (eCrCl) and plasma total homocysteine (tHcy) in hypertensive patients with a normal serum creatinine level.
Design and methods
A total of 137 hypertensive patients (mean age 66.6 years, 69 men) with serum creatinine level ≤ 1.5 mg/dL gave 10-h fasting blood samples for measurement of tHcy, serum folic acid, and serum vitamin B12.
Results
95 patients fell into a chronic renal insufficiency (CRI) group (eCrCl ≤ 60 mL/min/1.73 m2) and 42 into a normal renal function (NRF) group (eCrCl > 60 mL/min/1.73 m2). The CRI group was older (p < 0.001), had higher tHcy (p < 0.001), higher serum urea nitrogen (p < 0.001), higher serum creatinine (p < 0.001), lower eCrCl (p < 0.001), and lower diastolic blood pressure (p = 0.001). In univariate analysis, eCrCl had the strongest correlation with tHcy (r = − 0.453, p < 0.001). Significant correlations, ranging in decreasing order from r = − 0.418, p < 0.001 to r = − 0.170, p = 0.047, were also noted between tHcy and twelve other variables. In multivariate analysis, only eCrCl (p < 0.001), usage of fibrate (p < 0.001), serum level of vitamin B12 (p = 0.002), serum level of folic acid (p = 0.009), and smoking (p = 0.027) were independent predictors of tHcy.
Conclusion
eCrCl is a strong independent predictor of tHcy in hypertensive patients with normal serum creatinine.