Enantioselective addition of carbon acids to 伪-nitroalkenes: the first asymmetric aminocatalytic reaction in liquefied carbon dioxide

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• 作者：A.G. Nigmatov ; I.V. Kuchurov ; D.E. Siyutkin ; S.G. Zlotin ; ^{zlotin@ioc.ac.ru}
• 关键词：Organocatalysis ; Bifunctional tertiary amine ; Asymmetric Michael addition ; Liquid carbon dioxide
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：4 July, 2012
• 卷：53
• 期：27
• 页码：3502-3505
• 文件大小：444 K

摘要

Carbon acids, in particular malonates, malononitrile, and anthranone, react enantioselectively with 伪-nitroalkenes in the presence of Takemoto鈥檚 organocatalyst in liquid carbon dioxide medium (100 bar, rt), under homogeneous conditions, to afford the corresponding Michael adducts in moderate to high yields and with enantioselectivities comparable with those obtained in organic solvents.