- 作者：So-Yeon An ; Min Suk Lee ; Sang-A Yi ; Eun Suk Ha ; Seung Jin Han ; Hae Jin Kim ; Dae Jung Kim ; Kwan-Woo Lee ; lkw65@ajou.ac.kr
- 关键词：FGF21 ; fibroblast growth factor 21 ; BMI ; body mass index ; TG ; triglycerides ; HDL ; high density lipoprotein ; LDL ; low density lipoprotein ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; HbA1c ; hemoglobin A1c ; ACR ; albumin to creatinine rat
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2012
- 期刊代码：78_01688227
- 类别：med
- 出版时间：May, 2012
- 卷：96
- 期：2
- 页码：196-203
- 文件大小：377 K
Aims
Fibroblast growth factor 21 (FGF21) is an important regulator of glucose/lipid metabolism. Although there are studies examining the relationship between serum FGF21 levels and glucose homeostasis, the role of FGF21 remains unclear. The objective of this study was to examine whether serum FGF21 levels are associated with metabolic parameters in subjects with varying degrees of obesity and glucose tolerance and with complications in subjects with type2 diabetes mellitus (T2DM).Methods
The study consisted of 213 subjects who were lean and had normal glucose tolerance (lean NGT), were overweight with NGT, had impaired glucose tolerance (IGT) or had T2DM. Serum FGF21 levels and their associations with the parameters of adiposity, glucose tolerance and the presence of diabetic complications were examined.
Results
The serum FGF21 levels in T2DM were higher than in lean NGT. Serum FGF21 levels showed a positive correlation with the urine albumin-to-creatinine ratio (ACR) in all subjects except for the T2DM subjects, who showed a correlation after adjustment of age, gender and body mass index. Moreover, the subjects with carotid artery plaque showed higher serum FGF21 levels than those without complications.
Conclusion
Serum FGF21 levels were associated with the urine ACR and diabetic complications including carotid artery plaque.