Enzyme-promoted desymmetrisation of prochiral bis(cyanomethyl)phenylphosphine oxide

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• 作者：Piotr Kieł ; basiń ; ski ; Michał ; Rachwalski ; Mał ; gorzata Kwiatkowska ; Marian Mikoł ; ajczyk ; W ; a M. Wieczorek ; Mał ; gorzata Szyrej ; Lesł ; aw Sieroń ; ; Floris P.J.T. Ru
• 关键词：Cyclizations ; Heterocycles ; Medium-sized rings ; Ring-closing metathesis ; Silyl enol ethers
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2007
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：4 September 2007
• 卷：18
• 期：17
• 页码：2108-2112
• 文件大小：235 K

摘要

Prochiral bis(cyanomethyl)phenylphosphine oxide has been successfully transformed into the corresponding optically active monoamide and monoacid with enantiomeric excesses ranging from low (15%) to very high (up to 99%) using a broad spectrum of nitrile-hydrolysing enzymes.