Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation
- 作者：Kyeong-Hee Lee ; Kyeong-Jin Moon ; Hyung Sik Kim ; Byong Chul Yoo ; Seoyoung Park ; Ho Lee ; Soim Kwon ; Eun Sook Lee ; Sungpil Yoon
- 关键词：SOCS ; Nuclei ; Cytoplasm ; Localization ; Proteasome inhibitor
- 刊名：FEBS Letters
- 出版年：2008
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：25 June 2008
- 卷：582
- 期：15
- 页码：2319-2324
- 文件大小：988 K
摘要
We investigated the cellular localization of ectopically-expressed CIS, SOCS1, SOCS2 and SOCS3 proteins. We found that SOCS proteins localize to the nucleus where they reduce Stat3 proteins and that the presence of proteasome inhibitors increased SOCS nuclear localization. Our results indicate that increased nuclear localization resulted from increased levels of SOCS proteins in the cytoplasm. Finally, we demonstrate that the same effect occurs with endogenously-expressed SOCS proteins. These observations suggest that increased cytoplasmic levels of proteins in the SOCS family are regulated through nuclear translocation.