- 作者：Kyeong Ho Yun ; Myung Ho Jeong ; Seok Kyu Oh ; Eun Mi Lee ; Je Lee ; Sang Jae Rhee ; Nam Jin Yoo ; Nam-Ho Kim ; Young Keun Ahn ; Jin-Won Jeong
- 关键词：Thyroid gland ; Coronary disease ; Arteriosclerosis
- 刊名：International Journal of Cardiology
- 出版年：2007
- 期刊代码：128_01675273
- 类别：med
- 出版时间：31 October 2007
- 卷：122
- 期：1
- 页码：56-60
- 文件大小：185 K
Methods
We studied 344 angina patients (62.5 ± 9.72 years, male 50%) who underwent elective coronary angiography. TSH, free thyroxine, serum lipid levels and high-sensitivity C-reactive protein levels were measured and compared to the severity of coronary artery disease.
Results
In patients with high level of TSH (≥ 2.1 μIU/mL), age (p = 0.016), the levels of serum creatinine (p = 0.004) and Gensini's score (p = 0.016) were significantly higher than those in patients with low TSH levels. The incidence of multi-vessel disease was higher in patients with high TSH level (p = 0.026). TSH level showed a significant correlation with age (r = 0.109, p = 0.044) and Gensini's score (r = 0.117, p = 0.045). The multivariate analysis revealed that age (OR 2.39, p = 0.001), diabetes (OR 3.74, p = 0.001), creatinine (OR 2.06, p = 0.008), and smoking (OR 1.85, p = 0.045) were independent predictors for significant coronary artery disease, but TSH level did not predict coronary artery stenosis.
Conclusions
Although the high level of serum TSH is associated with multi-vessel disease, it was not the determinant of coronary artery disease in patients with normal range of thyroid function.