Glucocorticoid receptor variant and risk of dementia and white matter lesions

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• 作者：Elisabeth F.C. van Rossum ; Frank Jan de Jong ; Jan W. Koper ; André ; G. Uitterlinden ; Niels D. Prins ; Ewoud J. van Dijk ; Peter J. Koudstaal ; Albert Hofman ; Frank H. de Jong ; Steven W.J. Lamberts ; Mo
• 关键词：Dementia ; Glucocorticoid receptor ; Polymorphism ; Alzheimer's disease ; White matter lesions
• 刊名：Neurobiology of Aging
• 出版年：2008
• 期刊代码：202_01974580
• 类别：med
• 出版时间：May 2008
• 卷：29
• 期：5
• 页码：716-723
• 文件大小：164 K

摘要

Elevated glucocorticoid levels are associated with dementia. A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities.