Improved detection of recurrent laryngeal tumor after radiotherapy using ¹⁸FDG-PET as initial method

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• 作者：Jolijn Brouwer ; Remco de Bree ; Emile F.I. Comans ; Mohammed Akarriou ; Johannes A. Langendijk ; Jonas A. Castelijns ; Otto S. Hoekstra ; C. René ; Leemans
• 关键词：Recurrent laryngeal carcinoma ; Radiotherapy ; ¹⁸FDG-PET ; Interobserver variability
• 刊名：Radiotherapy and Oncology
• 出版年：2008
• 期刊代码：231_01678140
• 类别：med
• 出版时间：May 2008
• 卷：87
• 期：2
• 页码：217-220
• 文件大小：116 K

摘要

Timely detection of recurrent laryngeal tumor after radiation is an important predictive factor for curation as well as preservation of laryngeal function. Direct laryngoscopy under general anesthesia with taking of biopsies is the standard diagnostic procedure to detect recurrence when suspicion is raised. This, however, is an invasive and potentially damaging technique. Hence, a non-invasive diagnostic procedure, such as ¹⁸FDG-PET to stratify patients for direct laryngoscopy could be useful. ¹⁸FDG-PET is interpreted visually so that observer variation may affect clinical practice. In the present study, we therefore investigated this aspect of reproducibility.