A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia
- 作者：Xin Li ; xin_li6666@mail.hust.edu.cn ; Juan Li ; Yanjie Hu ; Wei Xie ; Wen Du ; Wei Liu ; Xiaoqing Li ; Xiangjun Chen ; Hongrui Li ; Junfeng Wang ; Lannan Zhang ; Shiang Huang
- 关键词：Acute lymphoblastic leukemia ; Additional cytogenetic abnormalities ; Chromosomal abnormalities ; Cytogenetic abnormalities ; Cytogenetics ; Molecular cytogenetics
- 刊名：Leukemia Research
- 出版年：2012
- 期刊代码：186_01452126
- 类别：med
- 出版时间：June, 2012
- 卷：36
- 期：6
- 页码：720-726
- 文件大小：226 K
摘要
Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1;19), +8, 12q鈭? +21, +22 and high hyperdiploidy with 51-65 chromosomes, and lower incidences of t(9;22) and 鈭?/5q鈭?than adult ones (all p < 0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.