Effects of pulsed infra-red low level-laser irradiation on open skin wound healing of healthy and streptozotocin-induced diabetic rats by biomechanical evaluation

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• 作者：Masoomeh Dadpay^a ; ^{dadpay_m@yahoo.com} ; Zanelabedien Sharifian^b ; ^{vahidsharif@yahoo.com} ; Mohammad Bayat^b ; ^{bayat_m@yahoo.com} ; ^{mohbayat@sbmu.ac.ir} ; Mehrnoush Bayat^c ; ^{mehr_bayat@yahoo.com} ; Ali Dabbagh^d ; ^{alidabbagh@yahoo.com}
• 关键词：Infra-red laser ; Low-level laser therapy ; Diabetes ; Skin ; Wound healing process ; Tensile strength
• 刊名：Journal of Photochemistry and Photobiology B ; Biology
• 出版年：2012
• 期刊代码：67_10111344
• 类别：ch
• 出版时间：4 June, 2012
• 卷：111
• 期：Complete
• 页码：1-8
• 文件大小：726 K

摘要

Diabetes is one of the most common causes of delayed wound healing. Low-level laser therapy (LLLT) are one of the therapeutic modalities used for the treatment of wounds. The aim of present study is to evaluate the effect of LLLT in experimentally-induced diabetic rats.

Two full thickness skin incisions were made on dorsal regions of each rat. The wounds were randomly divided into laser-treated and placebo. Laser-treated wounds of the healthy (non-diabetic) animals were submitted to a pulsed-infrared 890 nm laser with an 80 Hz frequency and 0.03 J/cm² for each wound point in the first healthy group and 0.2 J/cm² in the second healthy group. Laser-treated wounds of the diabetic animals received the same pulsed-infrared laser treatments as the second group for each wound point. On day 15, a sample from each wound was extracted and submitted for tensile strength evaluation. Laser irradiation with 0.03 J/cm² significantly decreased the maximum load for wound repair in healthy rats (p = 0.015). Laser irradiation with 0.2 J/cm² significantly increased the maximum load in wounds from the healthy control (p = 0.021) and diabetic (p < 001) groups. Laser treatments with a pulsed infrared laser at 0.2 J/cm² significantly accelerated wound healing in both healthy and diabetic rats.